We’re nearly at the halfway point of the 2025 college football season. And there could be some season-defining games in Week 7, with three matchups between ranked opponents and plenty more important clashes going down on a packed Saturday.
Here’s what we’re keeping an eye on today (and here’s how to watch college football this weekend):
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No. 1 Ohio State (-14.5) at No. 17 Illinois
Noon ET, Fox
Illinois has had mixed results against ranked opponents, but the stink of that 63-10 loss to Indiana may never fully wear off unless the Illini can somehow pull the upset on Saturday. If Illinois couldn’t block Indiana, can it block Ohio State?
No. 8 Alabama (-3) at No. 14 Missouri
Noon ET, ABC
The Crimson Tide are 10-0 at home under Kalen DeBoer but just 3-5 away from Bryant-Denny Stadium since the start of 2024. This will be the battle of Alabama QB and Heisman candidate Ty Simpson vs. Missouri’s sleeper Heisman candidate in running back Ahmad Hardy.
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No. 7 Indiana at No. 3 Oregon (-7)
3:30 p.m. ET, CBS
After Indiana faced criticism for its lackluster performance against ranked opponents a year ago, the Hoosiers needs to prove themselves against Oregon. Saturday’s game is a draft nerd’s dream with Indiana QB Fernando Mendoza and Oregon QB Dante Moore going head to head.
No. 6 Oklahoma (-1) vs. Texas
3:30 p.m. ET, ABC
The betting line moved in favor of OU after ESPN reported Thursday night that Sooner QB John Mateer is set to attempt to play after having surgery on his hand a few weeks ago. On the other side of the Red River Rivalry is Texas QB Arch Manning, who has gotten a lot of grief after he’s failed to live up to his lofty preseason expectations. He’ll face a massive challenge against a fierce Oklahoma pass rush.
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No. 15 Michigan at USC (-2.5)
7:30 p.m. ET, NBC
Michigan freshman QB Bryce Underwood has played well at home while struggling in two road games. That doesn’t bode well for him on Saturday, when he’ll have to match a USC offense that leads the nation at 8.5 yards per play behind QB Jayden Maiava.
