James O’Connor will play his first Test in the northern hemisphere in four years after being recalled by Australia to face Ireland in Dublin on Saturday (20:10 GMT).
The 35-year-old will start at fly-half for the Wallabies under Joe Schmidt, who faces the side he led to three Six Nations title as the predecessor to current Irish head coach Andy Farrell.
Australia have lost five of their last six matches and their two autumn Tests with England and Italy have both ended in defeat.
“We’ve tried to get some freshness into this squad,” said Schmidt.
“There’s a bit of wear and tear, to be honest, and we’re just trying to mitigate some of the wear and tear and get a fresh 15 out there.”
Leicester Tigers’ O’Connor, who made his first Australia appearance in three years against the British and Irish Lions in July, will partner Jake Gordon at half-back after missing the Wallabies’ three most recent games against Japan, England and Italy.
Len Ikitau returns to join Joseph-Aukuso Suaalii at centre, while Harry Potter retains his place on the wing and will start in the back three alongside Filipo Daugunu and Max Jorgensen.
Ulster-bound prop Angus Bell is named in the front row alongside Matt Faessler and the returning Allan Alaalatoa.
Tom Hooper moves from the back row to lock, as Rob Valetini joins Fraser McReight and captain Harry Wilson in the pack.
“I’ve learned a long time ago, you can’t please all the people all the time, but we’ve got to build some depth,” added Schmidt, who will be replaced by Les Kiss next year.
“I feel like if you don’t have strength in depth, you’re too vulnerable. But how do you learn and how do you get better? I think the only way to do it is in the arena, and at some stage, you’ve got to trust everyone in your squad.
“If you’ve selected them, then they have to be ready for whatever is demanded of them once they put on a Test jersey.”
Australia: M Jorgensen; F Daugunu; JA Suaalii, L Ikitau; H Potter; J O’Connor, J Gordon; A Bell, M Faessler, A Alaalatoa; J Williams, T Hooper; R Valetini, F McReight, H Wilson (capt)
Replacements: B Pollard, T Robertson, Z Nonggorr, N Frost, C Tizzano, R Lonergan, T Edmed, A Kellaway.