While Henderson is a notable omission, he is not the only big name missing from last year’s Six Nations squad.
The injuries to key players like Porter, Henshaw and Baird are a blow, while Peter O’Mahony, Cian Healy and Conor Murray have all retired.
The average caps of last year’s squad under interim head coach Simon Easterby was 44.1.
This year, that has fallen to 28.4 as Farrell returns following his stint with the British and Irish Lions.
In terms of Henderson, Ferris added that there was “young blood snapping at the heels” of the Ulster second row, but he believes the 33-year-old could have a role to play in the wider squad with his experience.
Munster’s Edogbo will add an exciting presence for the forward pack, while Tom Ahern and Cian Prendergast are also exciting options.
“Is this the changing of the guard? Is this Andy Farrell wanting to bring in some of the younger guys?” Ferris said.
“They might be some of the guys he wants to call upon at the next World Cup.”
Farrell said Ireland know they have “to hit the ground running” in Paris on 5 February.
“The squad has evolved over the last 18 months, with 12 players making their international debuts over the last year alone, and I know how keen this group is to make its mark for Ireland,” he said.