Home US SportsNCAAF Week 6 college football best bets, odds, picks: My best bets for Week 6

Week 6 college football best bets, odds, picks: My best bets for Week 6

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We’ve reached the point of the college football season where reality sets in. Some September darlings are regressing, injuries are mounting and coaches are starting to feel real heat. The oddsmakers have more data to lean on, but so do we, and that means opportunities remain if you can read between the numbers. This week’s board features several totals that stand out, plus one matchup where tempo and revenge collide.

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Let’s dive into three bets worth locking in to cap off our betting week.

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No. 24 Virginia at Louisville (-6.5, 61.5)

Virginia enters this game fresh off the program’s biggest win in years, a wild 46-38 double-overtime thriller over No. 8 Florida State. The Cavaliers got a gutsy performance from QB Chandler Morris, who played through a second-half hand injury. That injury lingers into this week, and it looms large against a Louisville defense that is one of the nation’s best in pressure rate.

The market has been sharp in Virginia totals all season, and for good reason. The Cavaliers offense relies heavily on Morris, but he’s already thrown four interceptions in five games and looked particularly erratic when forced outside the pocket. Louisville’s front has the speed and depth to exploit that weakness.

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On the other side, Louisville’s rushing attack is poised for a breakout game. Virginia gave up 216 rushing yards to NC State and 256 to Florida State in consecutive games, and now Cardinals RBs Isaac Brown and Duke Watson enter healthier than they’ve been all year. Sustained drives from Louisville combined with Virginia’s inconsistent red-zone execution set up a game script where points won’t pile up quickly.

Bet: Under 61.5

Clemson (-14, 46.5) at North Carolina

This is the classic “get-right” spot for Dabo Swinney.

Clemson’s offense has been inconsistent, Cade Klubnik has already matched two-thirds of last year’s interception total, and the Tigers managed just 27 points against Troy. This game against UNC sets up as a release valve. The Tar Heels defense has been shredded by competent offenses and doesn’t have the depth to survive four quarters against Clemson’s talent. North Carolina, meanwhile, has been one of the ACC’s most disappointing teams.

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Whether QB Gio Lopez is healthy or not, the Tar Heels have struggled to move the football against quality opponents. Coming off a bye, though, there’s at least some hope that adjustments were made. If UNC can generate even modest offensive production, it helps this total climb.

The bigger angle here: Dabo doesn’t take his foot off the gas in spots like this. Clemson has a long track record of running up scores against vulnerable opponents, and the matchup against UNC’s soft defensive front could get ugly. The Tigers may be below their usual offensive ceiling, but this is the exact type of game where they put up 35-plus on their own.

Bet: Over 46.5 (-115)

No. 16 Vanderbilt at No. 10 Alabama (-10.5, 55.5)

This sets up as a revenge game for Alabama, but the style points toward a quieter scoreboard. Vanderbilt plays at one of the slowest tempos in the nation, snapping the ball later than all but a handful of FBS teams. Their goal is to shorten games, limit possessions and avoid giving superior opponents chances to snowball momentum.

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Alabama has shown flashes of explosiveness, but this is not the quick-strike Tide offense of years past. Ty Simpson has been efficient, but this group plays more methodically. Combine that with Vanderbilt’s clock-draining approach, and drives figure to be longer, even if they end in points. The Commodores’ defense is also better than its reputation.

Head coach Clark Lea’s fingerprints are all over a unit that’s generating havoc (43 TFLs, 14 sacks already) and holding opponents to 13 fewer points per game than two years ago. Alabama will find mismatches, but Vanderbilt’s scheme should force the Tide to work for touchdowns rather than rattle off explosive plays.

Bet: Under 55.5

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